A principal in the McKee, Fuller Co.

He followed his elder brother, James W. Fuller, to Catasauqua, and there he was engaged throughout his life as a contractor, being an eminent builder of bridges and large structures. One of his projects was the replacement of the Crane Iron Company Bridge after it had been swept away during the Flood of 1862. He was appointed postmaster of Catasauqua in 1862 and he served as such until 1865. He also served as a member of the Catasauqua School Board during the year of 1863. Early in 1865, Charles D. Fuller was one of the organizers of the Catasauqua Oil Company, which purchased land in Venango County for oil speculation. In 1866, in the company of William R. Thomas I, he organized the Lehigh Car, Wheel and Axle Company at Fullerton, which was in turn acquired by the firm of McKee, Fuller and Company.

During the invasion of Pennsylvania in the summer of 1863 by Lee's Army of Northern Virginia, Charles D. Fuller enlisted as a private in Co. B, 38th Pennsylvania Volunteer Infantry. He and his family resided in their fine residence, located on the north side of Bridge Street, between Fourth and Crane Streets.