Edward Fuller, the eldest son of Robert Fuller, was baptized at Revenhall, Norfolk, England. About the year 1607 or 1608 he fled to Holland with his brother, who was a physician and deacon. The name of Edward Fuller appears as the twenty-first signer of the compact drawn up on board the "Mayflower" previous to the landing of her passengers at Plymouth Rock in November 1620. His wife is supposed to have been Anne, "who died soon after they came on shore."