After leaving school he was engaged in various enterprises, but because of an illness of heart disease he lived retired for some years. In 1905, George H. Williams along with Rowland T. Davies and Winifred (Williams) Emanuel formed a limited partnership under the name of the Catasauqua Real Estate Company, and as such in 1906, erected sixteen fine brick dwelling-houses along Pine Street, between Limestone and Third Street; Third Street, between Pine and Walnut Street; and Limestone Street, between Pine and Walnut Street.

George H. Williams died at the Pennsylvania Hotel, northeast corner of Second and Bridge Streets, on March 7, 1919, and his remains were interred in the Williams family plot at Fairview Cemetery.